Mario Winans is a member of gospel music's most notable family The Winans by marriage as he is the son of Bishop Ronald E. Brown and Vickie Winans older brother of Marvin Winans Jr. of Detroit, Michigan also god-brother to Alvon L.D. Cruse of Trenton, New Jersey Minster of music for Love Fellowship C.O.C.W.I.H. where the Pastor is Bishop David V. Williams Jr. (NOTE: Bishop Ronald E. Brown was Vickie Winans first husband, but Mario took the Winans last name after her marriage to Marvin Winans).

Winans started out learning music in school learning piano, keyboards, and drums. His mother Vicki Winans bought him a roomful of recording equipment, and he learned the function of every piece of equipment. He started producing gospel groups straight out of high school and soon accumulated credits for Fred Hammond, The Anointed Clark Sisters as well as various Winans family member albums.